At the level of the region, the commitment in the National Program of Inter-corporate Synergies corresponds to what is called "metabolism approaches" at the micro level on the presented schema. The purpose of this document deals, according to the modeling presented, with metabolism approaches at the macro scale. This type of approach benefits from the precedence of work already carried out at the national level (CGDD, 2013) or sub-national (Barles, 2009, EME, 2011, Alterre Bourgogne, 2013, Georgeault, 2015) and the method for carrying out this exercise was gradually built on the basis of the publications of the European Statistical Office (Eurostat, 2001, 2009) and the recent guide of the French Ministry of Ecology (CGDD, 2014). French know-how in the field is real and according to the United Nations, concerning the observation of the materiality of territories, "the most sophisticated framework has been developed by Barles based on the Paris city-region" (UNEP, 2013 , p34). This is the path taken by public policies to produce the monitoring indicators dedicated to the circular economy (Aurez & Georgeault, 2016). We have chosen to produce these indicators on the basis of the framework that is slowly becoming the norm while adding more traditional socio-economic considerations to situate the territories in a broader trajectory and comparing, as far as possible, with the national results. This technical achievement should enable stakeholders to better understand the materiality of the local socio-economic system and to feed their reflections and analyzes.