This report deals with an Material Flow Analysis (MFA) for the region Centre Val de Loire in France. It was driven by the DREAL Centre-Val de Loire which wanted to get a regional MFA. This MFA will allow to analyze those main flows which get inside the system, to be transformed, stored or dischared in the nature. In order to so, the DREAL asked the CEREMA to realize this MFA according to the Region Centre-Val de Loire characteristics. Based on this study, the DREAL's aim was also to design more efficient resource strategies and management.